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However, more studies are needed to clarify how mechanical stretching regulates the production of growth factors and induces macrophage polarization (Figure 3)
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We used murine Acly flox/flox hepatocellular carcinoma (HCC) cell lines and generated isogenic cell lines lacking ACLY or ACSS2 via adenoviral Cre treatment or CRISPR/Cas9 gene editing, respectively (Supplemental Figure 1A)
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