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Notably, the alterations induced by MNAM treatment were abrogated upon Sirt1 knockdown

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5-amino-1MQ, an analogue from our initial series of NNMT inhibitors with low IC50 value (IC50=˜1 μM), and high cell membrane permeability (Table 5), produced the greatest reduction of intracellular 1-MNA levels at a concentration of 10 μM among tested inhibitors