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Consistent with this, a recent study in a maternal immune activation mouse model found that offspring exhibited hyperactivation of the PI3K/AKT/mTOR pathway alongside suppressed autophagic function and elevated NLRP3 inflammasome activity, and that pharmacological mTOR inhibition with rapamycin restored autophagic activity, reduced NLRP3-dependent neuroinflammation, and ameliorated schizophrenia-like behavioral abnormalities [84]
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