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Consequently, it would be difficult to identify negative regulators of Bdnf transcription using our screening assay, because luciferase protein would be stably expressed and luciferase activity would not be easily reduced even if Bdnf transcription is prevented by negative regulators
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However, it also said that a double dose of the booster shot — 100 micrograms, rather than the approved 50 micrograms — was significantly more effective
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