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Without semaglutide, participants relying solely on lifestyle changes shed approximately 2.4% of their weight in the same period

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However, excessive ammonia accumulation induces a novel form of cell death in effector T cells, termed Ammonia death ( Distinct from traditional cell death mechanisms such as apoptosis, necrosis, and pyroptosis, ammonia-induced cell death (termed “Ammonia death”) is a novel form of cell death triggered by overload of glutamine-derived ammonia, leading to the demise of effector T cells