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Thus, the gut microbiota can be a major modulator of Kyn pathway in different mental disorders, impairing tryptophan metabolism and influencing the brain and systemic inflammation [226]

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In the 1990s, Japanese researchers found that in children 5 years old or younger with low BH4 levels, supplemental tetrahydrobiopterin significantly improved autism symptoms in some.[ref] (To be clear, not all children with autism have low BH4 levels, nor will all respond to BH4)