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The lowest level of antioxidant intake or tissue concentration results in nutrient deficiency if the antioxidant is essential (vitamins and minerals)
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Elucidation of this substrate-turnover-dependent regulation of CDO activity began with the discovery of this rare intramolecular cross-link between active-site residues Cys93 and Tyr157 in the X-ray crystal structure of CDO (Simmons et al
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