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Another commonly used technique is the Ice pack test where ice is filled in a thin surgical glove and kept against the closed eyelid of a seated patient for 2–5 min

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KA receptor is composed of GluR5–7 and KA1/2 subunits forming a tetrameric channel ( Figure 2 ) ( 3 Glutamate transporters/exchangers and regulation of glutamatergic signaling in the TME The maintenance of the balance between the extracellular and the intracellular glutamate is made by transporters, that are expressed by tumor and immune cells