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[26] [118] Pharmacologically, tramadol is similar to tapentadol and methadone in that it not only binds to the MOR, but also inhibits the reuptake of serotonin and norepinephrine [14] due to its action on the noradrenergic and serotonergic systems, such as its "atypical" opioid activity
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These tests support membrane permeability and are consistent with the later rat oral-bioavailability result
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