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Development and distribution of microglia in central nervous system Microglia are derived from yolk sac progenitors that seed the brain around 4.5 weeks of gestation in the human brain and appear only when blood circulation develops.[170] Subsequent studies strongly support a mesodermal origin that corresponds to a selective macrophage population (myeloid precursors).[127] Microglia possess specific antigen expressing profiles, proliferative potentials, morphology subtypes, and functions not present in macrophages.[38] Microglia enter the brain via the meninges and choroid plexus
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