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To understand the transcriptional changes driving this G2/M arrest, we treated p53 wild-type PEDS_0041_T1 with DMSO or KPT-330 using the IC50 concentrations (e.g., 6 µM) for 24 hours and performed RNA-sequencing (“Methods”)

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They might recommend oral contraceptives (for women), spironolactone, or other medical treatments