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The protective mechanism of methionine is likely due to its conversion to sulfur-containing amino acids, including cysteine, which are depleted by the renal excretion of sulfated acetaminophen metabolites (50)
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In hypoxic settings, erythropoiesis is meticulously regulated by the activation of the hypoxia-inducible factor (HIF) pathway, which largely enhances erythropoietin (EPO) synthesis in renal peritubular cells (53)
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