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In animal cells the fate of ITCs is well characterized: conjugation to glutathione by GSTs resulting in its intracellular depletion and subsequent degradation of dithiocarbamates through enzymatic events catalysed by γ-glutamyltranspeptidase, cysteinylglycinase and N -acetyltransferase via the mercapturic acid pathway 76
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For example, it has been found that polydatin promotes mitochondrial biogenesis and protects against mitochondrial oxidative stress via the activation of Sirtuin-1-PGC-1α pathway and Sirtuin-1-Nrf2-ARE pathway in kidney diseases (Huang et al., 2015
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