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Benzyl alcohol has been associated with serious adverse events and death in pediatric populations, particularly neonates, due to: Immature metabolic pathways for benzyl alcohol detoxification Accumulation of benzyl alcohol and its metabolite (benzoic acid) “Gasping Syndrome” – characterized by metabolic acidosis, gasping respirations, CNS depression, and cardiovascular collapse For neonatal research applications, use only preservative-free Sterile Water for Injection

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Increased amyloid beta precursor protein (APP) and beta-secretase 1 (BACE1) transcription was the result of this histone hyperacetylation and DNA hypomethylation, potentially as a result of an increase in NF-B activity (Gu et al., 2013)