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In a Portuguese study, the SELENOS − 105G/A promoter polymorphism (rs28665122) was strongly associated with circulating levels of cytokines such as IL-1β, IL-6, and TNF-α, known to be involved in the pathogenesis of HT ( Reference Schomburg and Kohrle 71 , Reference Santos, Duraes and Mendes 73 )
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