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For instance, Bifidobacterium bifidum , a potent immunomodulator in human diseases, induces the production of regulatory T cells (Verma et al., 2018), regulates helper T cell 2 and Th17-mediated immune responses in the intestine, inhibits the production of pro-inflammatory cytokines such as TNF-α, IL-6, IL-1β, IL-18, IL-22, and IL-9, while promots the expression of anti-inflammatory cytokines such as IL-10, IL-4, and IL-5 ( Faecalibacterium prausnitzii, Clostridium, Eubacterium rectale , and Roseburia —demonstrate pronounced enrichment under these conditions

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Chemical structures of lipoic acid and lipoyllysine residue The figure illustrates the chemical structures of lipoic acid in its oxidized and reduced forms, its two enantiomers ( R - and S -lipoic acid), and its covalent attachment to a lysine residue of the E2 component of the α-ketoacid dehydrogenase complex (and the H protein of the glycine cleavage system), forming a lipoyllysine moiety