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The combination of these adjuvant agents with standard doses of opioids can be used to reduce the risk of complications (e.g., constipation, dizziness, nausea, vomiting, respiratory depression, tolerance, physical dependence) seen in patients using high-dose opioids to alleviate CIPN symptoms
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These changes may underlie some of the cognitive and neuropsychiatric symptoms observed in CD and appear to improve following adherence to a GFD (Lanza et al
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