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Additionally, lycopene cleavage products can be generated through autoxidation, via reaction with free radicals [186], by processes that simulate biological tissues [187], or even by chemical reactions that cause the interruption of the polyene chain, affecting the carbon-carbon double bond system, and by addition or cleavage, resulting in several isomers and apo-lycopenoids [159,188]
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Acquired resistance to BET-PROTACs (proteolysis-targeting chimeras) caused by genomic alterations in core components of E3 ligase complexes
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