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Mechanisms of APAP-induced Liver Injury Mechanistic studies of APAP hepatotoxicity started with the recognition that a part of the dose of APAP is metabolized by cytochrome P450 (Cyp) enzymes [6], now known to be mainly Cyp2E1 [22], which generates a reactive metabolite that can be detoxified by GSH [9]
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Acute inflammatory responses in the airways and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers
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