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In agreement with the literature, the investigated sweeteners of this study showed noticeable docking scores with human 3β-HSD (PDB: P14060) ranging from −7.8 kcal/mol for aspartame to −7.1 kcal/mol for sucrose, −6.4 kcal/mol for sucralose, and finally −4.7 kcal/mol for sorbitol (Figure 3), which constitutes potential inhibition for progesterone and represents a fatal danger in pregnancy

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Therefore, inhibition of negative regulators of WNT/β-catenin pathway is also a potential therapeutic approach for AGA treatment