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2 Biomaterials promote the generation of CAR-T cells The conventional CAR-T therapy includes several steps, such as plasma apheresis from the patient, flow-sorting cells, CAR virus preparation, infection of CAR virus with T cells, expanded culture of CAR-T cells, and transfusion back to the patient after quality inspection ( Figure 2 ) ( in vitro , biomaterials can even rapidly and specifically program tumor recognition capabilities into T cells as they circulate in vivo ( Figure 3 )