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In summary, ferroptosis is intimately linked to the initiation and progression of AD, PD, MS, and ALS, as evidenced by strong concordance between findings from clinical human samples and those derived from animal and in vitro models

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Clinical observations indicate that elevated lactate levels (hereafter “lactate” refers to cerebral lactate unless otherwise specified) are associated with persistent brain edema and neurological deficits (Tobieson et al., 2019)