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Ferroptosis is a type of cell death driven by uncontrolled peroxidation of membrane phospholipids. Glutathione peroxidase 4 (GPX4) is the main regulator of ferroptosis, but how it protects membranes is not well
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Thus, in the metabolic transformations of the pentose phosphate pathway, part of the energy of glucose 6-phosphate is conserved in NADPH, a molecule with a negative reduction potential, that, therefore, can be used in reactions requiring an electron donor, such as fatty acid and steroid synthesis
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