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In a primary culture of orbital fibroblasts from GO patients and control subjects treated with H 2 O 2 to induce OS, the antioxidants vitamin C, N-acetyl-L-cysteine, melatonin, retinol, β-carotene and vitamin E were found to reduce the manifestations OS (proliferation of fibroblasts, the level of hyaluronic acid, the level of tumor necrosis factor-α (TNF-α), IFN-γ and IL1-β, which provided the basis for the possible clinical use of these substances in patients with GO (87)

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The sides are identical in area, and have the same depth distribution, therefore they also have the same pressure distribution, and consequently the same total force resulting from hydrostatic pressure, exerted perpendicular to the plane of the surface of each side