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The most reactive and toxic byproducts of lipid peroxidation are 4-hydroxynonenal (4-HNE) and malondialdehyde (MDA), which covalently modify cysteine, histidine, and lysine residues on critical mitochondrial proteins, disrupting complexes I and III of the respiratory chain (75, 76)
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10.1186/s12967-022-03579-1 28 FoudaA.AbdelazizA
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