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Thioether macrocycles targeting human Met ectodomain were selected using the RaPID system 13,39 , slightly modified as follows: 1 μM mRNA library was incubated with 1.5 μM puromycin linker in the presence of T4 RNA ligase for 30 min at 25 °C and was purified by phenol–chloroform extraction and ethanol precipitation
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