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Effect on body weight and safety of RC‐1291, a novel, orally available ghrelin mimetic and growth hormone secretagogue: results of a phase I, randomized, placebo‐controlled, multiple‐dose study in healthy volunteers
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In mature adipocytes, stimulation of NOX-dependent ROS by soluble UA triggered activation of p38 and ERK1/2 MAP kinases, decreased nitric oxide (NO • ) bioavailability, increased protein nitration and lipid peroxidation, and could be an indirect promoter of insulin resistance [63]
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