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In both DSS- and TNBS-induced mouse models, 5-HT 4 activation reduced inflammation in colons of mice with colitis, and, in noninflamed colons of wild-type mice, the inhibition of 5-HT 4 resulted in decreased epithelial proliferation and barrier dysfunction and increased bacterial translocation to the liver and spleen, with signs of colitis within 3 days after the administration of 5-HT 4 inhibitors [160]

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However, AS-IV administered at conventional biological doses is generally considered safe and has been widely developed as a bioactive component in various TCM preparations, such as Shen-Qi-Jiang-Tang and Zhen-Qi-Fu-Zheng granules and Qi-Shen-Yi-Qi pills (27)