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Based on the early, limited mechanistic understanding of acetaminophen hepatotoxicity, which included reactive metabolite formation and hepatic GSH depletion [58, 59], various antidotes with the capacity to replenish hepatic GSH levels were tested

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A series of alkanoates of 3-methyl-3-sulfanylbutan-1-ol ((CH 3 ) 2 C(SH)CH 2 CH 2 OC(O)R) and a series of alkanoates of 3-sulfanylhexan-1-ol (CH 3 CH 2 CH 2 CH(SH)CH 2 CH 2 OC(O)R) have been detected in the fruit peel of Poncirus trifoliata (a close relative of citrus) (Starkenmann et al., 2007)