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Despite these contradictory observations, there is no doubt that activation of AMPK leads to energy generation and promotion of survival signaling pathways, which finally protect against APAP-induced hepatotoxicity (Fig

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Data show concrete evidence of the existence of a bidirectional communication between the gut and brain (Mayer et al., 2022), gut and kidney (Evenepoel et al., 2017), and kidney and brain (Xie et al., 2022)