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The study also identified several risk factors for deficiency, including increased gestational age, higher parity, living in rented housing, and infrequent consumption of red or organ meat
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However, new impetus on the central role of B cells in MS pathogenesis was received from the identification in the meninges of SPMS patients of ectopic lymphoid follicles enriched with B and plasma cells, whose establishment in the brain of these individuals could provide a microenvironment in which B cell expansion and maturation, and hence local Ig production, may occur (Serafini et al., 2004)
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