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FOXO3 directly binds the BECN1 promoter under catabolic conditions such as fasting or muscle atrophy, promoting autophagosome formation
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Studies discovered mitochondrial-derived peptide called MOTS-c has been shown to significantly reduce the level of pro-inflammatory factors in mice and increase anti-inflammatory factors and insulin-stimulated glucose treatment rates, as well as glucose homeostasis (7–9)
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