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Ganglioside GD1a has notably been shown to be reduced in frontal gray matter and white matter in patients with Rett syndrome, a neurodevelopmental disorder associated with autism-like behavior and behavioral disturbances ( Escherichia coli lipopolysaccharide-induced inflammation in murine RAW264.7 macrophages by suppressing phosphorylation of mitogen-activating protein kinases and nuclear translocation of NF-κB family members through the Toll-like receptor 4 signaling pathway ( in vitro ( In vivo , injection of GT1b into the substantia nigra resulted in the death of nigral neurons, a finding associated with activation of microglia ( In light of their biological actions, the observed results for GT1b in the striatum, frontal cortex, and hippocampus could have contributed to the poor performance of the WVK-treated rats in the Morris water maze and open field as these regions are directly linked to the tasks associated with these tests