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Sirtuin 5 (SIRT5), which can be overexpressed in lung cancer 40 , can desuccinylate GLS to suppress its enzymatic activity 41 , while SIRT3 can deacetylate GLS2 to promote its increased activity with caloric restriction 42

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125 Acamprosate, a nonselective NMDA receptor antagonist originally approved for alcohol dependence, demonstrated favorable outcomes in two double-blind clinical studies