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It is a modified GHRH(1-29) analog designed to resist enzymatic breakdown and extend duration of action through albumin binding.¹² Key features of CJC-1295 DAC CJC-1295 with DAC: Activates the GHRH receptor on pituitary somatotroph cells Stimulates endogenous GH release Increases downstream IGF-1 signaling Binds to albumin through the DAC structure Produces sustained GH/IGF-1 effects over multiple days²³ Because of this extended exposure, CJC-1295 DAC is usually discussed in research contexts focused on longer-duration GH-axis activation rather than short GH pulses

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A review of clinical endpoints in advanced breast cancer