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Once activated, LXRs bind to specific DNA sequences known as LXR response elements (LXREs) in the promoters of target genes, leading to the transcriptional regulation of several key proteins involved in lipid metabolism (39, 40)
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Therefore, focus has been drawn towards targeting the glutathione antioxidant system in tumor cells as a therapeutic approach using drugs to target glutathione directly, indirectly, or by using glutathione-based prodrugs (Figure 4) [15]
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