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These findings highlight the key role insulin plays in modulating hepatic responsiveness to GH and support the notion that insulin plays an important part in regulating hepatic GH sensitivity via its ability to directly influence GHR expression and GH binding

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In an animal model with cholinergic deficit (scopolamine) and in models of neurodegeneration, improvements were reported in the Morris water maze at working concentrations on the order of nanograms per kilogram of body weight — values many orders of magnitude lower than for most studied nootropic small molecules

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