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For example, selective inhibitors of the phosphodiesterase type 5 (PDE5), an enzyme known to degrade cGMP by hydrolytic cleavage of the phosphodiester moiety, such as sildenafil (VIAGRA™), vardenafil (LEVITRA™), tadalafil (CIALIS™), avanafil (SPEDRA™) and udenafil (ZYDENA™), have been successfully used to treat male erectile dysfunction (ED) in large populations of patients with different organogenic etiologies of the disease [45]

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Clinically, rapid, noninvasive MB testing enables early FGTB detection, allowing timely antitubercular therapy initiation to improve fertility outcomes and quality of life