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111 These findings indicate that PI3K signalling regulates metabolic homoeostasis in the liver through two distinct pathways: one involving AKT-dependent glucose uptake, and the second requiring PKCζ/λ to sustain lipid synthesis
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At concentrations covering several orders of magnitude, dofetilide blocks only IKr with no relevant block of the other repolarizing potassium currents (e.g., IKs, IK1)
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