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(1) MR overactivation increases NADPH oxidase activity to induce a series of oxidative stress responses in adult rat models, leading to the inflammatory and fibrotic process, finally results in the cardiac lesions such as myocardial hypertrophy, ventricular remodeling, myocardial ischemia/infarction, and ultimately to the development and progression of cardiovascular disease and renal disease ( Figure 1 )