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6 week hormonal acne update- using 100ng spiro (2 months now), GHK-CU copper peptide 2% (6 weeks now) and Sculptra (3 months now). I'm now adding Azelaic to help with scarring
From a mechanistic point of view, metformin can reduce histone acetylation at the CCR8 promoter and inhibit CCR8 expression on tumor-infiltrating Treg cells by upregulating AMPK-activated Sirtuin 2 (SIRT2), thus enhancing the effectiveness of anti-PD-1 immunotherapy (73)
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