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Another miRNA, miR-184, was found to be upregulated in renal tubules from Zucker diabetic fatty rats with overt nephropathy, and associated with collagen accumulation and reduced expression of lipid phosphate phosphatase 3 (LPP3), an enzyme involved in the clearance of the pro-fibrotic mediator lysophosphatidic acid (85)

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And many of these conditions (especially if comorbid with another, such as having both type 2 diabetes and hypertension) are associated with a reduced quality of life and increased mortality.1 Additionally, experts note that diet and nutrition — including nutrient deficiencies — contribute to the development of chronic disease.2 Unfortunately, most Americans are deficient in one or more micronutrients.3 With this in mind, you may be wondering how to go about filling in these nutritional gaps, and that’s where supplement companies like Life Extension try to step in and help