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Tocopherols and tocotrienols are found to clamp NF-κB and JAK-STAT3 (kinase-signals transduction and activation of transcription) signalling pathways, mediators of various proinflammatory cytokines, including interleukin-1 (IL-1), interleukin-6 (IL-6), and TNFα
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The degeneration of these neurons leads to the characteristic cupping of the optic disc and, ultimately, vision loss (1) (Figure 1)
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