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Leucine-973 is a crucial residue differentiating insulin and IGF-1 receptor signaling [PMID: 36548088] Laboratory literature summary: Leucine-973 is a crucial residue differentiating insulin and IGF-1 receptor signaling
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Inhibition of system xc - impairs cystine uptake, resulting in diminished GSH levels that subsequently reduce the activity of membrane lipid repair enzyme GPX4 and compromise cellular antioxidant capacity [78]
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