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GPx1 knockout mice exhibit mild pancreatitis substantiated by diminished β cell mass, mild impairment of insulin secretion, and decreased fasting insulin levels (Brigelius-Flohé and Flohé 2020)

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Since there is increased OCTN2 expression in the small intestine in response to oxidized fat, and OCTN2 binds not only carnitine but various drugs, it is suggested by the authors that OCTN2 might be harnessed to improve absorption of various drugs [112]