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301 Notably, ERdj5 activates SERCA2b at a lower level of Ca 2+ within the ER lumen, whereas a higher level of Ca 2+ within the ER lumen results in the formation of ERdj5 oligomers that are no longer capable of interacting with SERCA2b, suggesting the importance of crosstalk among Ca 2+ levels and proteostasis in the ER
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