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CL19035

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Dykstra Environmental Protection Agency, Washington DC, United States Explanation Evaluation for acceptable daily intake Biochemical aspects Absorption, distribution, and excretion Biotransformation Toxicological studies Acute toxicity Short-term studies of toxicity Long-term studies of toxicity and carcinogenicity Genotoxicity Reproductive toxicity Multigeneration reproductive toxicity Developmental toxicity Comments Toxicological evaluation References Explanation Dimethipin was first evaluated by the 1985 Joint Meeting (Annex 1, reference 44), when a temporary ADI of 0-0.003 mg/kg bw was established on the basis of a NOAEL of 100 ppm, equivalent to 2.5 mg/kg bw per day, in a 90-day study in dogs treated in the diet