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Dose-Response Evidence from Preclinical Gastroparesis Models The clearest dose-response data comes from induced gastroparesis models using either cysteamine (which causes duodenal ulcers that impair pyloric function) or L-NAME (a nitric oxide synthase inhibitor that paradoxically causes delayed emptying through vascular dysfunction)
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From a therapeutic standpoint, this suggests that antioxidant strategies might need to be tailored—for example, therapies targeting NO/peroxynitrite pathways might be more relevant before splenectomy, whereas broader antioxidants (or iron chelation to reduce Fenton chemistry) remain important throughout
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