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Milk Thistle (Silymarin)
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Tryptophan metabolism is significantly dysregulated, with increased kynurenine, 3-hydroxykynurenine, quinolinic acid, and xanthurenic acid, alongside reduced serotonin and melatonin precursors, indicating enhanced neuroinflammatory signaling, excitotoxicity via NMDA receptor activation, and disruption of circadian regulation [84,85]
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