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In the negative-ion mode, they facilitated the deprotonation of the terminal carboxyl group of the analyte, generating negatively charged molecular ions
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This has helped the discovery that the NMDAR plays an important role in many physiological processes such as synaptic plasticity and transmission, learning and memory as well as in pathophysiological conditions such as Parkinson’s, Huntington’s, schizophrenia and stroke [6]
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